Report #9
Artemisinin



What is Artemisinin?

Writes James Schaller, M.D. :


Artemisia is a revolutionary herb that is the source for many new medications such as artemisinin. The derivatives of this herb are so important that the World Health Organization and many other medical agencies recommend that approximately 400 millions yearly malaria victims should receive this as part of their malaria treatment.

This means a Chinese herb is the first line treatment for a massive medical illness. This information is stunning and historic. Allopathic physicians do not prescribe herbs, and the FDA dos not even allow physicians to prescribe herbs and make specific health claims for any of them.

Dr. Robert Jay Rowen M.D. writes at http://www.springboard4health.com/store/artemisinin.html :


While I never recommend that my patients treat their cancer by themselves, there is now an herb I can recommend wholeheartedly thatís safe and can be used at home and in conjunction with doctor-administered therapies. This isnít just a supplement to help build your immune system. This herb aggressively fights cancer.
Artemesia is a simple plant that grows in Southeast Asia. Iíve used it for years to treat intestinal parasites. The World Health Organization lauds it as a safe malaria treatment. I discovered the cancer connection when Drs. Henry Lai and Narenda Singh, bio-engineering professors at the University of Washington, reported on the active agent of this Asian herb (artemisinin). Their report said the herb ďmight provide a safe, non-toxic, and inexpensive alternative for cancer patients.Ē What I didnít realize was that artemesia is a close cousin to oxygen therapy. Chinese researchers said the key to its effects was a peroxide linkage (two oxygen atoms hooked together) within the herbís active molecule.
Then, one year ago, an article appeared in a major cancer journal demonstrating significant artemisinin anticancer activity in a wide variety of laboratory cultured cancer cells. But astonishingly, cancerís resistance to common chemotherapy drugs shows no such resistance to artemisinin. It does not have the chemical structure a cancer cell requires to develop resistance! (This was reported recently in the International Journal of Oncology 18; 767-773, 2001 by Efferth, et al.)
Dr. Hoang recommends treatment for two years. Cancer could be like the malaria parasite. If just one cell remains, it can find its way back. Thus, as in malaria, although the parasite is cleared in a few days, prolonged treatment best prevents relapse. And the beauty of this treatment is that it is non-toxic, so you can continue taking it indefinitely with no expected sided effects.

Dr. Hoang reports that 500 mg twice daily of oral artemisinin by itself is the dosage he has been using with great success.

The product is best taken on an empty stomach with some natural fat to enhance absorption. Any iron present from residual food may neutralize the peroxides. Mile is one of the few foods with minimal iron. Whole milk, cottage cheese or yogurt have ample fat to enhance absorption. Additionally, I believe simultaneous administration of cod liver oil (for its omega-3 and vitamin D) and conjugated linoleic acid (CLA) will assist absorption, while providing therapeutic benefits.
To date, with the exception of patients very near death, taking artemisinin or derivatives have stabilized, improved, or remitted every cancer patient I have followed.


Artemisinin passes the blood/brain barrier, according to Dr. Henry Lai, and is selective to cancer cells. It has very low toxicity, none at therapeutic doses.

Artemisinin or Qinghaosu (pronounced Ching-hao-su) is an extract from the plant Artemisia annua (sweet wormwood) or Qinghao (pronounced Ching-hao).  Artemisinin triggers the death of cancer cells through apoptosis.  Scientific research has also shown Artemisinin to be beneficial in balancing the microbiology of the gastrointestinal tract.

Artemisinin is an anti-parasitic and anti-angiogenic.  It is essentially a method of delivering hydrogen peroxide (Gammill, 11/29/04).


http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=168984
Publication Type: Proceedings/Symposium
Publication Acceptance Date: November 15, 2003
Publication Date: January 15, 2004
Citation: Ferreira, J.F. 2004. Artemisia annua L.: The hope against malaria and cancer. Proceedings of the 2nd Annual Symposium, Appalachian Opportunities, Medicinal and Aromatic Plants: Production, Business & Applications. Mountain State University/USDA, ARS, Appalachian Farming Systems Research Center, pp. 56-61.
Artemisia annua produces a compound named artemisinin (qinghaosu), which kills both Plasmodium falciparum (the malarial agent) and cancer cells in a similar manner.

At http://www.altcancer.com/docs/artemisinin.pdf Dr. Lai and Dr. Singh, senior research scientists at the Department of Bioengineering, University of Washington, explain how artemisinin functions as an anti-cancer agent.

Artemisinin becomes cytotoxic (cell killing) in the presence of ferrous iron. Cancer cells require much more iron to multiply than normal cells do. To accommodate a rate of iron intake greater than normal cells, cancer cells' surfaces feature greater concentrations of transferrin receptors - cellular pathways that allow iron into a cell. Breast cancer cells have 5 to 15 times more transferrin receptors on their surface than normal breast cells. During a recent study, both breast cancer cells as well as normal cells were injected with artemisinin. The results showed that artemisinin effectively killed radiation-resistant breast cancer cells in vitro, without harming healthy cells.

Writes Dr. Lam, M.D., at http://www.drlam.com/opinion/artemisinin_study_abstracts.cfm :

In another study, researcher Dr Lai noted even more amazing results involving leukemia cells. He mentioned that the cancer cells were destroyed very quickly within a few hours when exposed to holotransferrin (which binds with transferring receptors to transport iron into cells) and dihydroartemisinin (a more water-soluble form of artemisinin). He further explained that it might be because of the high concentration of iron in the leukemia cells.
(H.Lai and NP Singh, Selective Cancer Cell Cytoxicity from Exposure in Dihydroartemisinin and Holotransferrin, Cancer Letters, 91:41-46, 1995)

This amazing herb was also examined for its activity against 55 cancer cell lines (Developmental Therapeutics program of the National Cancer Institute, USA). It was found to be the most active against leukemia and colon cancer and active against melanomas, breast cancer, prostate cancer, CNS and renal cancer. It was also reported that artemisinin's effectiveness was comparable with other standard drugs used to combat cancer (without any toxic side effects).
(Efferth et al, Anti-Malaria Drug is Also active against cancer, Int'l Journal of Oncology, 18;767-773,2001.)

One cannot help but wonder, after such remarkable results at the National Cancer Inst., why are most medical doctors completely unaware of artemisinin's anti-cancer capabilities?

According to Dr. Rowen, M.D., "artemisinin may be a most effective method, and certainly one of the easiest, of delivering a knockout oxidative stress to cancer cells."
Also, "Dr. Singh, in a personal communication to me, has shared that he has been following a series of cancer patients with nearly universal improvement on artemisinin or its derivatives. He believes artemisinin will prove to be the most powerful, yet extremely inexpensive and safe, chemotherapeutic agent yet found, and effective orally for home use."

For a number of clinical case reports, please read http://www.townsendletter.com/Dec2002/artemisinin1202.htm.
Particularly remarkable is the following information from Dr. Rowen:
Brain Tumors
One young boy in New York who was confined to bed and unable to walk with a glioblastoma was able to get up and attend a sporting event within 10 days of taking artemether. A patient from Denmark, who had lost his hearing due to a brain tumor, regained it after a regimen of artemether. Another young boy has been doing well without surgery and radiation.

Various Oral Dosages Used
The exact best dosage schedule has yet to be determined. Physicians report mostly using artemisinin derivatives in the amount of 1 to 2 mgs per kilogram of body weight, once or twice a day. A kilogram is 2.2 lbs. Using the doctor suggested formula of 1 mg/kg of body weight, a 160 lb. person would weigh 72.7 kgs and might be prescribed 70 mg of artemisinin derivatives.

Some people have used higher dosages to obtain their results. The woman with a stage-IV breast cancer who was back to work in four months, used 3 to 4 mg/kg of body weight as her daily dosage for a short time. The woman in Africa with the tongue tumor also used a higher amount for a week. Higher dosages may be neurotoxic after long-term use or may cause heart problems (read toxicity info below).

Dr. Singh has suggested that a person of 65 kg (145 lb.) might take a combination of a 100 mg capsule of artemisinin, a 60 mg capsule of artesunate and a 40 mg capsule of artemether once a day at bedtime with a glass of milk. He also writes that the correct dosage for a specific person needs to be determined on an individual basis.

On an Empty Stomach
The research professors and the physicians are all in agreement that these derivatives need to be taken on an empty stomach away from food, so that it will not interact with the iron in the food. In the evening this would mean at least two or more hours after the last meal.

Dr. Singh has suggested taking it with a glass of milk .

From http://www.northeastherbal.org/articles/articleartemisinin.htm comes the following information:

Artemisinin should not be combined with radiation therapy because radiation treatments release iron stored in cancer cells to surrounding tissue. For best results, patients are encouraged to wait until at least two months after their last radiation treatment before beginning artemisinin.

However, artemisinin is compatible with chemotherapy. In a study published in 2002, German researcher T. Efferth, Ph.D., tested artemisinin in combination with 22 chemotherapy drugs and found that artemisinin enhanced the drugs' effectiveness. When artemisinin is used in combination with chemotherapy, it should be taken several hours after the chemotherapy treatment ends. When taken in combination with chemotherapy, artemisinin does not alleviate chemotherapy's side effects.


I (the author of this report) contacted Dr. Henry Lai, one of the two senior research scientists at the University of Washington who are the pioneers of artemisinin research. According to Dr. Lai, "Quite a lot of new information on the use of artemisinin for cancer treatment has come up in the last several years. There are approximately 30 publications ... There are many people taking artemisinin for cancer treatment ... many of the patients reported improvement. "

"In laboratory studies of radiation-resistant breast cancer cells that have a high propensity for accumulating iron revealed that Artemisinin has 75 percent cancer-cell-killing properties in 8 hours, and almost 100 percent within 24 hours ...  Normal cells remained virtually unharmed." --Michael Lam, MD

In an article on the use of Artemisinin for cancer, a researcher at the Brewer Science Library cites it as being highly effective for breast cancer, lymphoma, and particularly leukemia. 

"More aggressive cancers such as pancreatic and acute leukemia ... respond even better.  Slower cancers, such as nonaggressive prostate cancers, do not respond as well.  It is effective with sarcoma, melanoma, larynx, ovarian, prostate (but PSA doesn't drop), brain (including neuroblastoma and GBM), renal, metastatic breast cancer, and drug-resistant cancers. Artemisinin is effective against a wide variety of cancers as shown in a series of successful experiments.  The most effective is leukemia and colon cancer.  Intermediate activities were also shown against melanoma, breast, ovarian, prostate, CNS and renal cancer.  Although artemisinin is insoluble in water, it is able to cross the blood/brain barrier ... , and may be particularly suitable for curing brain tumors together with Poly-MVA. In Vietnam it is used to arrest breast cancer. "

The following article was posted by Medical Research News:

Artemisinin is derived from the wormwood plant and has been used in China since ancient times to treat malaria. Earlier work by Henry Lai and Narendra Singh, both UW bioengineers, indicated that artemisinin alone could selectively kill cancer cells while leaving normal cells unharmed.

(The two researchers developed a more advanced form of the substance.)

The new compound appears to vastly improve that deadly selectivity (of artemisinin), according to a new study that appeared in a recent issue of the journal Life Sciences. In addition to Lai and Singh, co-authors include Tomikazu Sasaki and Archna Messay, both UW chemists.

"By itself, artemisinin is about 100 times more selective in killing cancer cells as opposed to normal cells," Lai said. "In this study, the new artemisinin compound was 34,000 times more potent in killing the cancer cells as opposed to their normal cousins. So the tagging process appears to have greatly increased the potency of artemisinin's cancer-killing properties."

In the study, researchers exposed human leukemia cells and white blood cells to the compound. While the leukemia cells quickly died, the white blood cells remained essentially unharmed.

The trick to the compound's effectiveness, according to Lai, appears to be in taking advantage of how cancer cells function.

Because they multiply so rapidly, most cancer cells need more iron than normal cells to replicate DNA. To facilitate that, cancer cells have inlets on their surface, known as transferrin receptors, in greater numbers than other cells. Those receptors allow quick transport into the cell of transferrin, an iron-carrying protein found in blood.

In creating the compound, researchers bound artemisinin to transferrin at the molecular level. The combination of the two ingredients appears to fool the cancer cell.

"We call it a Trojan horse because the cancer cell recognizes transferrin as a natural, harmless protein," Lai said. "So the cell picks up the compound without knowing that a bomb - artemisinin - is hidden inside."

Once inside the cell, the artemisinin reacts with the iron, spawning highly reactive chemicals called "free radicals." The free radicals attack other molecules and the cell membrane, breaking it apart and killing the cell.


What does artemisinin mean to the cancer patient?

Artemisinin can be used by leukemia and brain cancer patients. It is also effective against many other forms of cancer. It doesn't require intravenous application, it can be taken orally, by simply swallowing it. This makes it a very important and valuable anti-cancer agent, suitable for home treatment protocols. This is a very new compound against cancer, but already many people are using it, and the results are excellent.

Artemisinin is not a cure, and shouldn't be used as a monotherapy. In should be combined with other, compatible drugs or supplements in a comprehensive protocol.

Product Sources:

Holley Pharmaceuticals (1400 North Harbor Boulevard #550, Fullerton CA 92835, phone 1-866-8HOLLEY or 714-871-7070, www.holleypharma.com) sells artemisinin in 50-mg capsules (60 for $24.99, retail price) and 100-mg capsules (60 for $42.50). Holley offers wholesale prices and discounts for health care professionals.

Holley Pharmaceuticals artemether (40-mg softgels and tablets), artesunate (50-mg capsules), and other products derived from artemisinin are available only to healthcare professionals, research scientists, or customers living outside the United States. For information on these products, contact manager@holleypharma.com.

Allergy Research Group in Hayward, CA (phone 1-800-545-9960, www.allergyresearchgroup.com) offers three supplements derived from Sweet Annie that are sold in health food stores. Artemisia capsules contain 500 mg powdered Artemisia annua (120 capsules, $27, retail price); Artemisia Forte II capsules contain 150 mg Artemisia annua, 10 mg artemisinin, and 125 mg citrus seed extract (90 capsules, $40); and artemisinin capsules contain 100 mg artemisinin (90 capsules, $24).

Wellcare Pharmaceuticals (310-377-0056) in Los Angeles. The source most Americans are using. (www.hepalin.com). Tested by Dr. Singh

http://www.altcancer.com/artemis.htm

Dafra Company in Belgium (www.dafra.be)




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