Scientific Publications



  • Hidvégi M, Rásó E, Tömösközi-Farkas R, Paku S, Lapis K, Szende B:
The effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals. Anticancer Res 18: 2353-2358. 1998.

  • Szende B, Rásó E, Hidvégi M, Tömösközi-Farkas R, Paku S, Prónai L, Bocsi J, Lapis K:
A new substituted benzoquinone-containing product with antimetastatic properties. Orv Hetil 139: 2893-2897. 1998.

  • Hidvégi M:
The results of research concerning the effects of Avemar. Nogyógyászati Onkológia 3: 241-243. 1998.

1999

  • Hidvégi M, Rásó E, Tömösközi-Farkas R, Lapis K, Szende B:
Effect of MSC on the immune response of mice. Immunopharmacology 41: 183-186. 1999.

  • Hidvégi M, Rásó E, Tömösközi-Farkas R, Lapis K, Szende B:
MSC, a new benzoquinone-containing natural product with antimetastatic effect. Cancer Biother Radiopharm 14: 277-289. 1999.

2000

  • Jakab F, Mayer Á, Hoffmann A, Hidvégi M:
The first clinical data of a natural immunomodulator in colorectal cancer. Hepatogastroenterology 47: 393-395. 2000.

  • Boros L. G, Lee W-N. P, Hidvégi M, Go V. L. W:
The metabolic effects of fermented wheat germ extract with anti-tumor properties in cultured MIA pancreatic adenocarcino-ma cells. Combined Meeting of the International Association of Pancreatology and the American Pancreatic Association. Chicago, Illinois, USA, 1-5 November 2000. . .

  • Falkay Gy, Blazsó G:
The antiinflammatory effect of Avemar. The Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged scientific meeting. Szeged, 14 November 2000. . .

2000

  • Telekes A, Hidvégi M:
The effects of Avemar (1) anti-cancer effects in animals and tumor patients. Nogyógyászati Onkológia 5: 188-189. 2000.

2001

  • Boros L. G, Lapis K, Szende B, Tömösközi-Farkas R, Balogh Á, Boren J, Marin S, Cascante M, Hidvégi M:
Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells. Pancreas 23: 141-147. 2001.

  • Hidvégi M, Hoffmann A:
A new product in the supportive treatment of tumor patients. Hippocrates 3(1): 21-23. 2001.

  • Jakab F, Mayer Á, Hoffmann A, Hidvégi M:
Medium-term results of immunomodulation supplemented with MSC in the surgical treatment of colorectal carci-noma, incl. treatment of metastases. I. Congress of the Hungarian Society for Clinical Oncology. Budapest, 10-11 November 2000. (Abstract). LAM 11(Suppl1): 1. 2001.

  • Ribári O, Almay K, Hoffmann A, Hidvégi M:
Early experiences with supplementary Avemar treatment in patients with head/neck tumors. I. Congress of the Hungarian Society for Clinical Oncology. Budapest, 10-11 November 2000. (Abstract). LAM 11(Suppl1): 1. 2001.

  • Gidáli J, Hidvégi M, Fehér I, Lapis K:
The effect of Avemar on the regeneration of leukocytes, thrombocytes and reticulocytes in mice receiving sublethal radiation or cyclophosphamide. I. Congress of the Hungarian Society for Clinical Oncology. Budapest, 10-11 November 2000. (Abstract) LAM 11(Suppl1): 1. 2001.

  • Zalatnai A, Lapis K, Szende B, Rásó E, Telekes A, Resetár Á, Hidvégi M:
Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats. Carcinogenesis 22: 1649-1652. 2001.

  • Tompa A, Bíró A:
The role of Avemar (wheat germ extract) in enchancing the immunstatus of non-tumor patients. Obesitologia Hungarica Suppl 1(2): 1. 2001.

  • Ehrenfeld M, Blank M, Shoenfeld Y, Hidvegi M:
Avemar (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease. Lupus 10: 622-627. 2001.

  • Jakab F, Balogh Á, Mayer Á, Lapis K, Hoffmann A, Szentpétery Á, Telekes A, Hidvégi M:
Critical analysis of an anticancer supportive product (MSC) in colorectal patients. 11th World Congress of the International Association of Surgeons & Gastroenterologists in cooperation with the European Association of Endoscopic Surgery. Crete, 1-4 November 2001. (Abstract). Hepatogastroenterology Suppl I 48: CL. 2001.

  • Telekes A, Hidvégi M:
The effects of Avemar (2): immunological effects. Nogyógyászati Onkológia 6: 40-41. 2001.

  • Balogh Á:
The supportive value Avemar during chemotherapy. New results of the AVEMAR Cancer Research Program. Symposium. 24th Congress of the Hungarian Society for Oncology. Budapest, Hungary. 22-24 November 2001. . .

  • Jakab F:
Avemar on the survival and disease progression in colorectal cancer patients receiving complex oncological treatment. New results of Avemar Research Symposium. 24th Congress of the Hungarian Society for Oncology. Budapest, Hungary. 22-24 November 2001. . .

2001

  • Telekes A, Hidvégi M:
The effects of Avemar (3): signal transduction and meta-bolism. Nogyógyászati Onkológia 6: 144-145. 2001.

2002

  • Boros L. G, Cascante M, Lee W-N. P:
Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Drug Discovery Today 7(6): 18-26. 2002.

  • Boros G. L, Hidvégi M:
The effects of Avemar (4): modification of tumor meta-bolism. Nogyógyászati Onkológia 7: 239-241. 2002.

  • Boros L. G, Lee W-N. P, Go V. L. W:
A metabolic hypothesis of cell growth and death in pancreatic cancer. Pancreas 24: 26-33. 2002.

  • Fajka-Boja R, Hidvégi M, Shoenfeld Y, Ion G, Demydenko D, Tömösközi-Farkas R, Vizler Cs, Telekes A, Resetár Á, Monostori É:
Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines. Int J Oncol 20: 563-570. 2002.

  • Nichelatti M, Hidvégi M:
Experimental and clinical results with Avemar (a dried extract from fermented wheat germ) in animal cancer models and in cancer patients. Nogyógyászati Onkológia 7: 180-185. 2002.

  • Demidov L. V, Manzjuk L. V, Kharkevitch G. Y, Artamonova E. V, Pirogova N. A:
The antimetastatic effect of Avemar in high-risk melanoma patients. 18th UICC International Cancer Congress. Oslo, Norway. 30. June - 5. July 2002. (Abstract) Int J Cancer 100(S13): 408. 2002.

  • Cascante M, Boros L. G, Comin-Anduix B, Atauri P, Centelles J. J, Lee W-N. P:
Metabolic control analysis in drug discovery and disease. Nature Biotechnol 20: 243-249. 2002.

  • Comín-Anduix B, Boros L. G, Marin S, Boren J, Callol-Massot C, Centelles J. J, Torres J. L, Agell N, Bassilian S, Cascante M:
Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly (ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. J Biol Chem 277: 46408-46414. 2002.

2003

  • Hidvégi M, Moldvay J, Lapis K, Ajkay Z:
Fermented wheat germ-based product improves quality of life for lung cancer patients. Medicus Anonymus/Pulmono 11 (S1): 13-14. 2003.

  • Jakab F, Shoenfeld Y, Balogh Á, Nichelatti M, Hoffmann A, Kahán Zs, Lapis K, Mayer Á, Sápy P, Szentpétery F, Telekes A, Thurzó L, Vágvölgyi A, Hidvégi M:
A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 89: 465-469. 2003.

  • Tompa A, Kocsis Zs, Marcsek Z, Jakab M, Szende B, Hidvégi M:
Chemo-prevention with tamoxifen and Avemar by inducing apoptosis on MCF-7 (ER+) breast cancer cells. 2nd Congress of the World Society of Breast Health, Budapest, Hungary 24-28: 24-28. 2003.

  • Boros G. L, Hidvégi M:
Avemar effective supportive therapy in oncology. Hippocrates 5: 312-315. 2003.

2004

  • Garami M, Schuler D, Babosa M, Borgulya G, Hauser P, Müller J, Paksy A, Szabó E, Hidvégi M, Fekete Gy:
Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients. J. Pediatr Hematol Oncol 10: 631-635. 2004.

  • Ujpál M, Fülöp E, Farkas E, Hidvégi M, Paksy A, Szabó Gy:
Avemar: evident supportive effect in oral cancer. (Submitted for publication) . .

2004

  • Farkas E.:
The role of Avemar in oncolgy. A review.. Magy Belorv Arch 57: 4-9. 2004.

  • Stipkovits L, Lapis K, Hidvégi M, Kósa E, Glávits R, Resetár Á:
Testing the Efficacy of Fermented Wheat Germ Extract Against Mycoplasma gallisepticum Infection of Chickens. Poultry Science 11: 1844-1848. 2004.

  • Marcsek Z, Kocsis Zs, Jakab M, Szende B, Tompa A:
The Efficacy of Tamoxifen in Estrogen Receptor-Positive Breast Cancer Cells Is Enhanced by a Medical Nutriment. Cancer Biotherapy & Radiopharmaceuticals 6: 746-753. 2004.

2005

  • Illmer C, Madlener S, Horvath Z, Saiko P, A. Losert, Herbacek I, Grusch M, Krupitza G, Fritzer-Szekeres M, Szekeres T:
Immunologic and Biochemical Effects of the Fermented Wheat Germ Extract Avemar Experimental. Biology and Medicine 230/2: 144-149. 2005.

  • Farkas E.:
The role of Avemar in the complex treatment of tumors.. Paramedica IV/3. 2005.

  • Laszlo G. Boros, Michele Nichelatti, Yehuda Shoenfeld:
Fermented Wheat Germ Extract (Avemar) in the Treatment of Cancer and Autoimmune Diseases. Ann. N.Y. Acad. Sci. 1051: 529–542 . 2005.

  • András Telekes, Endre Kiss-Tóth, Tünde Nagy:
Synergistic Effect of Avemar on Proinflammatory Cytokine Production and Ras-Mediated Cell Activation. Ann. N.Y. Acad. Sci. 1051: 515–528. 2005.

  • Farkas Elek :
Fermented wheat germ extract in the supportive therapy of colorectal cancer. Orv Hetil 146: 1925–1931. 2005.

  • S. N. Lee, H. Park, K. E. Lee:
Cytotoxic activities of fermented wheat germ extract (Avemar) on human gastric carcinoma cells by induction of apoptosis. 2005 ASCO Annual Meeting Abstract No: 4254. 2005.

  • Bálint G, Apáthy Á, Gaál M, Telekes A, Resetár Á, Blazsó G, Falkay G, Szende B, Paksy A, Ehrenfeld M, Shoenfeld Y, Hidvégi M:
Effect of Avemar - a fermented wheat germ extract - on rheumatoid arthritis. Preliminary data. Clinical and Experimental Rheumatology 24: 325-328. 2006.

  • P. Saiko et al.:
Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells. Cancer Lett doi:10.1016/j.canlet. 2006.

This research program was supported by grants from the following organizations:
  • Hungary: Ministry of Education, Biotechnology 2000
  • Hungary: Ministry of Education, Biotechnology 2001
  • Hungary: OTKA (Hungarian Scientific Research Foundation)
  • Spain: Ministry of Science and Technology
  • Spain: Ministry of Health
  • USA: University of California Los Angeles (UCLA), General Clinical Research Center
  • USA: University of California Los Angeles (UCLA), Clinical Nutrition Research Unit
  • European Union: INCO-COPERNICUS
  • NATO: Scientific Program